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Information × Registration Number 0211U006294, 0108U001582 , R & D reports Title Pathogenetic role of cytokines in development of pathological process in children with acute lymphoblastic leukemia. popup.stage_title Head Dubey Leonid Yaroslavovych, Registration Date 09-03-2011 Organization LVIV RESEARCH INSTITUTE OF BLOOD PATHOLOGY AND TRANSFUSIONAL MEDICINE popup.description2 The depletion of whole T-lymphocyte subsets during intensive phase of chemotherapy were determinated. The high level both of IL-6 and TNF-alfa, as well as down level of IL-8 has been observed both at the beginning of disease and at the relapse. The close correlations between cytokines and blast cells in peripheral blood were detected. The correlation analyses between cytokines and main indexes of cellular and humoral immunity have shown impossibility perform its biological function isolated. In conclusion, the IL-6, IL-8 and TNF-alfa may be seen as a immunological indicator of childhood ALL course. Product Description popup.authors Дубей Наталія Василівна Калушка Віра Генадієвна Мазур Лілія Петрівна Матвієва Ірина Богданівна Мельник Віктор Євгенович Орлик Ігор Володимирович Сапужак Марина В'ячеславівна Семенюк Олександр Олександрович Ябчанка Володимир Володимирович popup.nrat_date 2020-04-02 Close