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Information × Registration Number 0211U006296, 0108U001581 , R & D reports Title Investigation of the mechanisms of ineffective haemopoesis and its interrelation with biological features of blood cells and bone marrow in myelodysplastic syndrome. popup.stage_title Head Masliak Zvenyslava Volodymyrivna, Registration Date 09-03-2011 Organization LVIV RESEARCH INSTITUTE OF BLOOD PATHOLOGY AND TRANSFUSIONAL MEDICINE popup.description2 In our study 56 patients with different subtypes of MDS were investigated. The aim of the study was to determine factors causing ineffective hemopoiesis in MDS and contributing to clonal evolution and transformation of the disease into acute leukemia. The obtained results suggest that important role in the course of MDS belongs to the synthesis and interrelation of certain cytokines. Ineffective hemopoiesis is apparently the consequence of the influence of TNF-alfa and probably another cytokine, TGF-beta, which at the late stages of MDS is able to stimulate proliferation of the malignant clones. This process along with angiogenesis activation, occurrence of additional gene mutations during intensified proliferation of genetically modified hemopoietic cells, results in disease progression to acute leukemia. These aspects have to be taken into consideration when managing the patients with MDS. Product Description popup.authors Бойко Ольга Ігорівна Виговська Ярослава Іллівна Даниш Ольга Йосипівна Зотова Олена Василівна Кароль Юрій Степанович Котлярчук Костянтин Богданович Лещук Остап Васильович Мазурок Анна Антонівна Мельник Марія Іллярівна Томашевська Наталія Яремівна Цяпка Орест Миколайович popup.nrat_date 2020-04-02 Close