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Information × Registration Number 0211U006506, 0110U005317 , R & D reports Title New biochemical approaches for evaluation of ecotoxicity of metallic nanoparticles based on determination of metallothioneins characteristics in water animals popup.stage_title Head Stoika Rostyslav, Registration Date 12-04-2011 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 Metal-binding protein metallotioneins (MTs) of mollusk Anodonta cygnea on expression level, functional activity and physico-chemical properties of the protein were studied under the effects of cobalt ions (Co), cobalt-containing nanomaterials (N) and the same polymer carrier (R) in environmentally realistic concentrations during 14 days. In group N cobalt accumulation in digestive gland tissue, expression of MT, reduced the level of active radicals (AR) were observed. For the group Co inherent significant increase of MTs metal-binding activity related to cobalt, copper, zinc and cadmium, as well as cytotoxicity, increased overall content of AR, cholinesterase activity, activation of apoptosis and estrogen-like effects. The specific features of group P were the unbalanced activities of the two phases of biotransformation: cytochrome P450-dependent (EROD) and glutathione-S-transferase activity and inhibition of apoptosis. Product Description popup.authors Стойка Ростислав Степанович Столяр Оксана Борисівна Філяк Євген Зеновійович Фальфушинська Галина Іванівна popup.nrat_date 2020-04-02 Close