Search academic texts

Information × Registration Number 0211U006524, 0109U006382 , R & D reports Title Development of mathematical models and methods of cerium dioxide nanoparticles experimental analysis at application, as a new generation protection of radiation. popup.stage_title Head Usatenko V. Alexander, Registration Date 14-04-2011 Organization Open international university of human development "Ukraine" popup.description2 The object of research - research on physical, chemical and biological mechanisms of radiation protection of biological objects in the application of nanoparticles of cerium dioxide as radioprotector new generation. Investigation of the influence of ceria nanoparticles on cell damage by free radicals in radiation injuries. The purpose of work - development of mathematical models that describe the radioprotective effect of nanoparticles of cerium dioxide on normal cells in biological objects in radiation injury and in cancer radiotherapy and experimental analysis techniques to study physical, chemical and biological processes of cerium dioxide nanoparticles protect normal cells and their targeted delivery to the damaged organs and further functionalization of cerium dioxide nanoparticles by modifying fluorofore. As the drug is applied original product cerium dioxide nanoparticles synthesized by us. The purpose of the second phase - the experimental study of the effect of nanoparticles of cerium dioxide on cell damage by free radicals in radiation injuries.The methods of study - physical and chemical analysis, regression analysis, Hencha method, the method of comparative molecular field analysis (CoMFA), spectroscopic methods, mikroflyuorometriyi and EPR, electron microscopy method, extraction and identification of DNA fragments by electrophoresis. Forecast assumptions about the object of research - will be synthesized nanoparticles of cerium dioxide originally a water-soluble ultrasmall nanoparticles of cerium dioxide using not toxic short-chain acrylic acid as a stabilizer. Product Description popup.authors Гамалія Микола Федорович Усатенко Олександр Васильович Ходзінський Олександр Миколайович Щербаков Олександр Борисович Ящук Валерій Миколайович popup.nrat_date 2020-04-02 Close