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Information × Registration Number 0211U006525, 0109U006382 , R & D reports Title Development of mathematical models and methods of cerium dioxide nanoparticles experimental analysis at application, as a new generation protection of radiation. popup.stage_title Head Usatenko V. Alexander, Registration Date 14-04-2011 Organization Open international university of human development "Ukraine" popup.description2 The object of research - research on physical, chemical and biological mechanisms of radiation protection of biological objects in the application of nanoparticles of cerium dioxide as radioprotector new generation. Investigation of the influence of ceria nanoparticles on cell damage by free radicals in radiation injuries. The purpose of work - development of mathematical models describing the radioprotective effect of nanoparticles of cerium dioxide on normal cells during biological radiation injuries and radiation therapy of cancer, as well as methods of experimental analysis on the physical, chemical and biological protection processes ceria nanoparticles normal cells and their targeted delivery to the damaged organs and further functionalization of nanoparticles of cerium dioxide by modifying the fluorophore. As the drug was used the original drug ceria nanoparticles synthesized by us. The comparative analysis of methods for synthesis of ceria nanoparticles and studied their physicochemical and biological properties and possible use in medicine in the radiotherapy of tumors. The purpose of the third phase - experimental animal studies of nanoparticles of cerium dioxide on normal and tumor cells as a function of nanoparticle concentration and pH in the radiotherapy of tumors. Methods of research - a method mikroflyuorometrii and EPR, electron microscopy, X-ray diffraction (XRD) samples, X-ray photoelectron spectroscopy and UV-visible spectroscopy, electron spin resonance (ESR), extraction and identification of DNA fragments by electrophoresis, fluorescence analysis per cell titers of cell viability (Promega), the definition of the absorption spectra spectrophotometer NanoDrop ND-1000, the definition of the kinetics of chemiluminescence (NIPKI "SPARK") and the method of voltammetry erythrocytes. Forecast assumptions about the development of the object of research - the synthesized original way to obtain ultrasmall soluble ceria nanoparticles of different sizes on a non-toxic based on using non-toxic short chain polyacrylic acid as a stabilizer, may be suitable for use in medicine, and also act as a cyto-and radioprotector new generation. Product Description popup.authors Гамалія Микола Федорович Усатенко Олександр Васильович Ходзінський Олександр Миколайович Щербаков Олександр Борисович Ящук Валерій Миколайович popup.nrat_date 2020-04-02 Close