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Information × Registration Number 0211U006558, 0109U006037 , R & D reports Title Research and development of a continuous flow based microfluidic chip for high-throughput cell electrofusion popup.stage_title Head Svir Irina Borisovna, Registration Date 21-04-2011 Organization Kharkiv National University of Radioelectronics popup.description2 The project is aimed at the development of a novel cell fusion method based on electroporation with direct current that will allow automatic cell pairing, fusion and separation of fused cells. The theoretical research is focused on transport of particles within a microchannel due to the combined effect of hydrodynamic and electrostatic forces. Research objectives were achieved through the application of various techniques of mathematical physics and numerical methods for the solution of partial differential equations comprising the core of the ensuing models. A new microfluidic system consisting of three microchannels connected with a reservoir (pool) has been proposed and studied theoretically. This system allows precise flow control to be achieved during the immobilisation of living cells or mixing/dilution of analytes. A new mathematical model of focusing of cells or particles in an electrophoretic microchannel of rectangular cross-section was proposed. Numerical solution of the corresponding problem of diffusion-convection-migration transport in a microchannel allowed the determination of the ranges of main geometrical, hydrodynamic and electrical parameters corresponding to best focusing of living cells. Product Description popup.authors Клименко Олексій Вікторович Олійник Олександр Ігорович Свірь Ірина Борисівна popup.nrat_date 2020-04-02 Close