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Information × Registration Number 0211U006559, 0109U006039 , R & D reports Title Theoretical and physico-chemical investigation of the vesicular transport of biochemical effectors in biology. popup.stage_title Head Oleinick Alexander Igorevich, Registration Date 21-04-2011 Organization Kharkiv National University of Radioelectronics popup.description2 In this work the theoretical investigation and mathematical modelling of processes related to the vesicular delivery of bioactive compounds within the living cell and to its external environment was carried out. Two different types of these processes were considered. First one is related to the diffusion of proteins at the spherical bilipid surface of a vesicle and the creation of a cluster at one of the poles of the vesicle. Created functional cluster is the centre of actin's polimerization and promotes building-up of the vesicle actin tail. The latter growth moves at the same time the vesicle within the cell. The second type of process concerns vesicular exocytosis, i.e. vesicle docking to the cell membrane, creation of a pore and emptying its content into extracellular space. Such processes are very important for the proper functioning of living organisms and occur, for instance, in neurons during the transfer of the excitation, in chromaffin cells during adrenalin secretion etc. For each of the mentioned types of vesicular transport a mathematical model was built and numerical simulation was carried out. Comparison of the obtained theoretical results with recent experimental data allows reconstruction of the values of main biochemical parameters as well as functional dependences, which characterize these complex processes. Product Description popup.authors Клименко Олексій Вікторович Олійник Олександр Ігорович Свірь Ірина Борисівна popup.nrat_date 2020-04-02 Close