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Information × Registration Number 0211U007618, 0110U000541 , R & D reports Title Mechanisms of formation of activity in neurons and neuronal networks of hippocampus under influence of tonic activation of dendritic receptors. popup.stage_title Head Korogod Sergiy M., Registration Date 21-07-2011 Organization International center of molecular physiology popup.description2 In the software environment of neurons were developed and tested computer model of hippocampal interneurons and their networks with shunting GABA-ergic synapses and tonic excitation. Were also carried out studies of the effect of tonic GABA-ergichenogo current synchronization processes in the network. In these studies, tonic current was characterized by two parameters: the reversal potential and conductance. It was found that the tonic current with reversal potential below the threshold of action potentials and reduced the frequency of synchronization bits in the network. It is also shown that the synchronization decreased steadily to increase the conductivity of the current. Determined the existence of a tonic conduction current, at which the dynamics of the neural network has a bi-stable character. So on the basis of the results concluded that the tonic inhibitory current decreases synchronization in a network of hippocampal interneurons and, depending on initial conditions in such a network can arise spontaneously synchronous oscillation, similar in nature to epileptic activity. Product Description popup.authors Кулагіна І.Б. popup.nrat_date 2020-04-02 Close