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Information × Registration Number 0211U007730, 0106U008149 , R & D reports Title Mining of methods of synthesis azote and sulfurcontainig of heterogeneous ring compounds and quinone imides popup.stage_title Head Harchenko Alexander, Доктор хімічних наук Registration Date 12-09-2011 Organization State higher educational entity "Ukrainian State University of Chemical Technology" popup.description2 Research object: ethyl ester 5-hydrazinocarbonyl-2 ,4-dimethyl-1H-pyrrole-3-carboxylic acid, alfa-sulfonil enamides Objective: To study the reaction heterocyclizations above compounds and their subsequent modification in order to obtain new potentially biologically active heterocyclic compounds. Method of study: organic synthesis, biological tests, chromatography, IR, NMR and MASS-spectroscopy. The behavior of esters 5 hydrazinocarbonyl-2 ,4-dimethyl-1H-pyrrole-3-carboxylic acid and alfa-sulfonil enamides in the reactions of heterocyclizations. The features of the course of these interactions. A series of new derivatives pirolotryazynoniv, 1,3-and 1,3-TIA-oksadyazoles were obtained. The reactivity of the obtained bicyclic systems were studied . A primary biological research were conducted. It was shown the prospects of further study of this objects as new and effective pharmaceuticals. According to the results of biological research "structure-leader" was proposed for further preclinical testing as an effective low toxic and hepatoprotective drug.Pharmaceutical Production DG 24.41.0 Product Description popup.authors Астахіна Валерія Олегівна Білов Володимир Віталійович Бельдій Олена Василівна Бойко Сергій Романович Воєвудський Максим Вадимович Карпіщенко Людмила Сергієвна Кисєльов Вадим Віталійович Крищік Оксана Володимирівна Ломинога Олена Олександрівна Марков Віктор Іванович Нічволода Віктор Михайлович Парамонова Тетяна Григорівна Харченко Олександр Васильович Чорноус Станіслав Юрійович Якименко Ігор Юрійович Янова Кароліна Валентинівна popup.nrat_date 2020-04-02 Close