Search academic texts

Information × Registration Number 0211U008145, 0110U000486 , R & D reports Title Identification of sex development peculiarities in children having systemic metabolic disorders born from parents been children themselves at the time of the ChNPP accident aiming the development of correction methods for the revealed disorders popup.stage_title Head Kovalenko A.N., Registration Date 06-04-2011 Organization Research Centre for Radiation Medicine popup.description2 Study subject - the children, born from persons been children themselves at the time of the ChNPP accident, suffering insulinresistance and lentinresistance syndromes at the background of obesity in the age of 10-16 years (100 persons), and compare group (having no such disorders) 50 persons. Study objective - to identify the peculiarities of pituitary-gonadal and thyroid systems and their effect on sexual maturation process in children having insulinresistance and lentinresistance at the background of obesity, that were born from parents been children themselves at the time of the ChNPP accident, and to develop the algorithm of diagnostics and correction of the revealed disorders. Study methods - clinical, anthropometrical, biochemical, hormonal assays, instrumental, statistical. Study results indicated that puberty period is critical for the insulinresistance initiation in children and adolescents. Peculiarities of sexual development in puberty period were revealed as an incidence increase of hypothalamic syndrome, appearing of multiple stretch marks, ovarian-menstrual cycle abnormalities in girls, hypogonadism and gynecomastia in boys. Disorders of hypothalamic regulation of pituitary function namely the shift of physiological LH/FSH ratio can be regarded as a main reason of sexual maturation rate deviations. It is stipulated by relative estrogen excess due to an intensified conversion of androgens to estrogens in adipocytes. Obesity is not a leading cause of sexual development disorders in children born from parents that were children themselves at the time of the ChNPP accident. Application of algorithm of diagnostics and correction of the thyroid diseases and somatic/sexual development disorders into the clinical practice within yearly scheduled health check-ups will promote the problem solving of respective disorders identification and optimization of prophylactic and curative arrangements. Product Description popup.authors Єгорова Ірина Вікторівна Афанасьєв Дмитро Євгенович Запісочний Олексій Захарович Копилова Ольга Василівна popup.nrat_date 2020-04-02 Close