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Information × Registration Number 0211U008869, 0107U011953 , R & D reports Title Development of diagnostic, treatment and prophylaxes measures for ecologically determined lesions of children, caused by intoxication with xenobiotics. popup.stage_title Head Hnateyko Oleh, Registration Date 17-11-2011 Organization Scientific-research institute of Hereditary pathology popup.description2 We conducted clinical, instrumental and laboratory examination of children from polluted areas of Ivano-Frankivsk region with different pathways of xenobiotics. Children from unpolluted areas were taken for control. We showed clinical variability of ecologically determined diseases, caused by similar pollutants, in cases of different ways of entering the human body. We outlined some molecular-genetic and biochemical markers of susceptibility to ecologically determined diseases in children from polluted areas - such as possessing GSTМ1 0/0 and GSTТ1 0/0 allele in genotype, lower alcoholdehydratase and NAT2 activity, increased glutationtransferase activity, high percentage of leukocytes specific lysis in presence of cadmium, cesium, strontium and lead salts. We also proved, that blood immunity status, adaptation reaction type, calcium blood and urine levels, leukocyte's specific lysis reactions in presence of heavy metals salts, levels of excretion of peroxide oxidation of lipids products and polar lipids with urine and urine-lysis tests can be used as diagnostic and prognostic markers in cases of various types of pollution. Product Description popup.authors Віштак Наталія Валентинівна Гнатейко Олег Зіновійович Кеч Наталія Романівна Косминіна Неля Станіславівна Лук'яненко Наталія Сергіївна Лучак Марта Володимирівна Печеник Сергій Олегович Чайковська Ганна Степанівна popup.nrat_date 2020-04-02 Close