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Information × Registration Number 0211U009081, 0107U012801 , R & D reports Title Investigation of molecular mechanisms of pathogenesis of the skin diseases, caused by fungi Candida, Malassezia and other micromicetes, for development of new methods of diagnostic popup.stage_title Head Bilozorov Olexiy Pavlovitch, Registration Date 17-06-2011 Organization Ukranian research institute of dermatology and venerology popup.description2 Object of investigation - pathogenesis of allergic dermatoses. Objective - To develop new molecular-genetic diagnostic methods for pathology due to Malassezia and Candida fungi and investigate processes of biofilms formation and effect on them Quorum Sensing autoinductors and antimycotics. Methods - clinical, immunological, microbiological, moleculer-genetic. Results - New molecular-genetic methods for detection of Malassezia fungi and evaluation of predisposition to atopic dermatitis and eczema were elaborated. 37 Malassezia spp and 29 Candida spp. strains were separated from skin of patients and typed with optimized cultivation and new molecular-genetic methods. In atopic dermatitis patients M.sympodіalіs и M.furfur prevailed and high level of specific anti-malassezia IgE antibodies was often determined. Genotype SPІNK5 1258АА and mutations FLG R501X и 2282del4 were shown to be associated with enhanced predisposition to atopic dermatitis and eczema, homozygotes in FLG mutation had more severe disease. Action of terbinafin upon planctonic forms and biofilms of Candida albicans have been significantly increased by addition of benzoil peroxyde, Quorum Sensing autoinductor farnezol and inhibitor of cyclooxygenase. Technolology of liposomal terbinafin production has been developed, this preparation was shown to express more strong antimycotic activity. Product Description popup.authors Євтушенко Тетяна Григорівна Іванова Н.Н. Білозорова Ольга Олексіївна Безрученко Іза Антонівна Васильченко В.М. Голуб Ганна Павлівна Зуєва Марія Ігорівна Кутасевич Яніна Францевна Мілютіна Олена Йосипівна Маштакова Ірина Олександрівна Олійник Ірина Олександрівна Частій Тетяна Володимирівна popup.nrat_date 2020-04-02 Close