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Registration Number

0211U009504, 0111U003674 , R & D reports

Title

Research of physico-chemical properties and bioactivity of synthetic macrocyclic nanoobjects and their functionalyzed derivatives towards the therapeutically important protein targets in vitro

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Head

Vovk A.,

Registration Date

26-12-2011

Organization

Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine

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It was established that new nanoscale molecules of functionalized derivatives of calixarenes may be able to inhibit human protein tyrosine phosphatases, including PTP1B. The kinetic studies in vitro revealed that some macrocyclic structures in this class are potent inhibitors of these enzymes with inhibition constant values in the micromolar range. Some of macrocyclic compounds were found to inhibit PTP1B selectively over the other protein tyrosine phosphatases.

Product Description

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І.М. Міщенко
В.Ю. Танчук
Л.В. Бабій
Н.В. Самусь
О.В. Музичка
Р.В. Бугас

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2020-04-02