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Information × Registration Number 0211U009504, 0111U003674 , R & D reports Title Research of physico-chemical properties and bioactivity of synthetic macrocyclic nanoobjects and their functionalyzed derivatives towards the therapeutically important protein targets in vitro popup.stage_title Head Vovk A., Registration Date 26-12-2011 Organization Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine popup.description2 It was established that new nanoscale molecules of functionalized derivatives of calixarenes may be able to inhibit human protein tyrosine phosphatases, including PTP1B. The kinetic studies in vitro revealed that some macrocyclic structures in this class are potent inhibitors of these enzymes with inhibition constant values in the micromolar range. Some of macrocyclic compounds were found to inhibit PTP1B selectively over the other protein tyrosine phosphatases. Product Description popup.authors І.М. Міщенко В.Ю. Танчук Л.В. Бабій Н.В. Самусь О.В. Музичка Р.В. Бугас popup.nrat_date 2020-04-02 Close
R & D report
Research of physico-chemical properties and bioactivity of synthetic macrocyclic nanoobjects and their functionalyzed derivatives towards the therapeutically important protein targets in vitro
Head: Vovk A.. Research of physico-chemical properties and bioactivity of synthetic macrocyclic nanoobjects and their functionalyzed derivatives towards the therapeutically important protein targets in vitro. (popup.stage: ). Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine. № 0211U009504
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Updated: 2026-03-22


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