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Information × Registration Number 0211U009519, 0111U005366 , R & D reports Title Design and synthesis of calixarene receptors for recognition and binding of biomolecules popup.stage_title Head Rodik Roman, Кандидат хімічних наук Registration Date 26-12-2011 Organization Institute of Organic Chemistry National Academy of Sciences of the Ukraine popup.description2 The object of research is the synthesis and study of physicochemical (including the ability to bind to NK) properties polycationic amphiphillic calixarenes, the goal is a molecular design and development of methods for synthesis of nanosized amphiphillic calixarenes functionalized with different receptor groups. The study of spatial structure, physico-chemical properties and investigation of the relationships "structure - activity" derived compounds. Broad range polycationic calix[4,6]arenes with choline-like ammonium groups on the upper rim macrocycle and hydrophobic groups on the lower rim were synthesized as a result of work. These calixarenes are able to self-assembling in aquatic environments and form nanosized micelles or aggregates up to 300 nm. Micelle-like particles can bind to DNA with resistance associates formed is directly proportional to the length of alkyl chains. Results can be implemented in biochemical and medical research. Product Description popup.authors Мірошниченко Станіслав Іванович Родік Роман Васильович Тернова Дар'я Сергіївна popup.nrat_date 2020-04-02 Close