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Registration Number

0211U013051, 0110U006324 , R & D reports

Title

Molecular mechanisms of regulation of genes expression involved in riboflavin biosynthesis and transport in flavinogenic yeasts.

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Head

Boretsky Yuriy Romanovych,

Registration Date

28-05-2012

Organization

Institute of cell biology, National Academy of Sciences of Ukraine

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It was found that iron deficient cells of P. guilliermondii possess dramatically reduced activity both of catalase and superoxide dismutase. Under condition of iron deprivation this yeast produces increased amounts of riboflavin and malondialdehyde - a marker compound of oxidative stress. P. guilliermondii gene encoding transcriptional factor that regulates expression of genes involved in oxidative stress responce was identified. This transcriptional factor has been shown to participate in regulation of both riboflavin biosynthesis and iron acquisition. P.guilliermondii insertional mutants that over-produce riboflavin were selected. Inactivation of P.guilliermondii gene encoding putative aminopeptidase leads to missregulation both of riboflavin biosynthesis and iron acquisition.

Product Description

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Дмитрук Костянтин Васильович
Пиняга Юрій Володимирович
Сибірний Андрій Андрійович
Фаюра Любов Романівна
Федорович Дарія Василівна
Яцишин Валентина Юріївна

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2020-04-02