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Information × Registration Number 0211U013089, 0111U004914 , R & D reports Title Search and characterization of oncogenes and tumor suppressor genes involved in the initiation and development of gliomas popup.stage_title Head Kavsan Vadym Musiyovich, Registration Date 16-12-2011 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 The project aim is a functional characterization of the new molecular markers - protein products of genes with altered expression in brain tumours that can be used for diagnostic and prognostic tumour evaluation. Among the genes overexpressed in glioblastoma, one can marked out the genes of chitinase-like cartilage CHI3L1 i CHI3L2 proteins. A study of oncogenic properties and proliferative potential of CHI3L1 and CHI3L2 proteins in the experiments with embryonic cell line 293 and human glioblastoma cell line U373 man was carried out. It was shown that CHI3L1 stimulates a cell growth and has an oncogenic potential. The peculiarities of MAPK- and PI3K-signaling pathways activation by CHI3L1 and CHI3L2 proteins have been investigated. It was demonstrated that CHI3L1 and CHI3L2 proteins activate the phosphorylation of extracellular signal-regulated kinases ERK1/2 and AKT proteinkinase as well, thus initiate the signaling cascades ERK1/2-MAP and RI3K Product Description popup.authors Єршов Антон Вікторович Арешков Павло Олександрович Балинська Олена Вікторівна Бойко Оксана Іванівна Букреєва Тетяна Василівна Дмитренко Володимир Володимирович Чаусовський Тімур Йосипович popup.nrat_date 2020-04-02 Close