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Information × Registration Number 0211U013141, 0110U006120 , R & D reports Title Development for technology target-specific search of aminoacyl-tRNA synthetases inhibitors with selective action against specific human infections. popup.stage_title Head Tukalo Mykhaylo, Доктор біологічних наук Registration Date 28-12-2011 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 The comparative study of humans and pathogenic bacteria Enterococcus faecalis prolyl-tRNA synthetases was carried out. Enzyme and ligand molecules were prepared for screening, and preliminary specific inhibitors search was accomplished. Score, presence and number of intermolecular hydrogen bonds and visual analysis of complexes with every of three ProRSEf subsites (ProRSEf "Full", ProRSEf "Base", ProRSEf "Pro") were used as selection criterions. From chemical compound library, that contains 100000 components, 150 most perspective compounds were selected for biological testing. Product Description popup.authors Бджола Володимир Григорович Бояршин Костянтин Сергійович Голуб А ндрій Григорович Гудзера Ольга Йосипівна Кpикливий Iван Андрійович Коваленко Оксана Петрівна Яpемчук Ганна Дмитрівна Ярмолюк Сергій Миколайович popup.nrat_date 2020-04-02 Close