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Information × Registration Number 0211U013256, 0110U004761 , R & D reports Title Development of new therapeutic approaches for chronic pain treatment with little side effect, which based upon genetic regulation of dynamic properties of spinal cord glutamate receptors. popup.stage_title Head Voitenko Nana Volodymyrivna, Registration Date 12-01-2012 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 We have discover molecular mechanism of an increase in Ca2+-permeability of synaptic AMPA receptors in substantia gelatinosa spinal cord neurons, which is mediated by internalisation of GluR2 subunit of AMPA receptors from synapses in substantia gelatinosa neurons in the conditions of peripheral CFA-induced inflammation. It has been shown an involvement of PKC in regulation of synaptic AMPA receptors functioning and internalisation of GluR2 subunit of AMPA receptors, as well as a key role of PKC in maintaining of chronic inflammatory pain. Product Description popup.authors Білан Павло Володимирович Войтенко Нана Володимирівна Вятченко-Карпинский В.Ю. Гончаренко Ю.В. Копач Ольга Володимирівна Хомула Євген Валерійович Черкас В.П. popup.nrat_date 2020-04-02 Close
R & D report
Development of new therapeutic approaches for chronic pain treatment with little side effect, which based upon genetic regulation of dynamic properties of spinal cord glutamate receptors.
Head: Voitenko Nana Volodymyrivna. Development of new therapeutic approaches for chronic pain treatment with little side effect, which based upon genetic regulation of dynamic properties of spinal cord glutamate receptors.. (popup.stage: ). Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine. № 0211U013256
1 documents found

Updated: 2026-03-22


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