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Information × Registration Number 0211U013257, 0110U004760 , R & D reports Title Molecular mechanismеs of plasticity of synaptic transmission from primary afferent neurons to the central nervous system popup.stage_title Head Veselovskiy Mykola Sergiyovych, Registration Date 12-01-2012 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 We examined properties of chemical neurotransmission at the level of primary afferent inputs into spinal cord using in vitro model of co-culture both the DRG and the DHSC neurons from newborn rats. The results of our studies showed presence of excitatory and inhibitory DRG neurons synapses on the cells of DHSC. The excitatory afferent signaling in such synapses was mediated by presynaptic release of glutamate and a following activation predominantly of AMPA-receptor subclasses. Either glycine- or GABA-ergic DRG neurons were involved in transmission of inhibitory signals to the DHSC neurons. However, in vast majority of examined neuronal pairs the inhibitory synaptic transmission was mediated by presynaptic release of glycine Product Description popup.authors Веселовський Микола Сергійович Кузнецов Кирило Ігорович Маслов Віталій Юрійович Федулова Світлана Анатоліївна Шипшина Марія Сергіївна popup.nrat_date 2020-04-02 Close