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Information × Registration Number 0211U013258, 0110U004755 , R & D reports Title Systemic and molecular mechanisms of cardiac remodeling and biotechnological methods of cardioprotection: regulation of gene expression encoding microRNA, factors of natriuretic protein system and proteins involved in cardiac failure progression popup.stage_title Head Moybenko Olexij Olexijovych, Registration Date 12-01-2012 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 A molecular genetic study was conducted in rats with cardiac remodeling of different genesis and after quercetin-containing experimental therapy. Coronary artery ligation and isoproterenol-induced cardiac remodeling caused increased gene expression of brain natriuretic peptide NPPB and its receptor NPR-A, whereas myocardial infarction also resulted in decreased gene expression of atrial natriuretic peptide NPPA and clearance receptor of these peptides - NPR-C. This suggests that the answer of genetic apparatus to cardiac damage of different genesis significantly differs in relation to genes of natriuretic sustem. Experimental therapy effectively influences the expression of studied genes only after myocardial infarction, causing 9-fold increase of mRNA NPPB level and 3-fold increase of mRNA NPR-A level. Product Description popup.authors Гур'янова Вероніка Леонідівна Досенко Віктор Євгенович Кузьменко Марія Олексіївна Мойбенко Олексій Олексійович Павлюченко Строй Дмитро Олександрович Тумановська Леся Володимирівна popup.nrat_date 2020-04-02 Close