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Information × Registration Number 0211U013260, 0110U004745 , R & D reports Title Investigation of the molecular mechanisms of the course of Alzheimer's disease at the molecular and cellular levels and their pharmacological correction popup.stage_title Head Kostyuk Olena Platonivna, Registration Date 12-01-2012 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 Using the method of patch clamp method in configuration "whole cell" the electrophysiological characteristics of voltage-dependent calcium channels were investigated. The changes in the voltage-current characteristics of low-threshold and high-threshold calcium channels in control conditions and in a model of Alzheimer's disease under the influence of ?1-42 amyloid were studied. It was found that incubation of hippocampal neurons in culture with ?1-42 amyloid increased the amplitude of current through voltage-activated calcium channels of neuron's culture and shifted the current-voltage characteristics of the calcium channel in the direction of negative values of membrane potential, which may indicate that the low-threshold calcium channels undergo greater changes than hight-threshold ones in terms of model of Alzheimer's disease. Product Description popup.authors Гамаюн Ігор Володимирович Король Сергій Васильович Король Тетяна Юріївна Костюк Олена Платонівна Романенко Сергій Вячеславович popup.nrat_date 2020-04-02 Close