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Information × Registration Number 0211U013270, 0110U005552 , R & D reports Title Determination of modification influenc of biocompatibility, dispersity and magnetic features of created materials. Investigation of nanopowder effects under influence of alternating magnetic field in vivo. popup.stage_title Head Osinsky Sergej P., Registration Date 12-01-2012 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 Investigation of synthesis of the substances series of AFe2O4 (A=Mn,Fe, Co,Ni,Zn) with spinel structure was performed, the magnetic features of AFe2O4 synthesized nanoparticles were determined, and values of magnetic saturation and coercive force in accordance with chemical composition (magnetization values: 3-33 А·m2/kg; coercive force 4.378-7.722 kA/m) were assessed. The ferrum oxide nanoparticles were obtained and studied in vivo. It was obtained that nanoparticles suspension in saline has not shown obvious toxicity under testing for acute toxicity, in the same time nanoparticles were kept in kidney and liver cells in 40 and 70 days after intravenous administration resulting in the reversible reactive alterations in tissue of these organs. Nanoparticles selectively enhance the level of hypoxia and acidity in tumor. Nanoparticles suspension is able to be heated in alternating magnetic field (AMF) as well as to heat the rat muscle by intratissue administration followed by influence AMF. Obtained results indicate the perspective of magnetic fluid creation on the basis of ferrum oxide nanoparticles with modified surface for the working out of nanohyperthemia method for malignant tumors. Product Description popup.authors Бубновська Лариса Микитівна Ганусевич Ірина Іванівна Гуменюк Ліля Дмитрівна Ковельська Антоніна Василівна Мамонтова Леся Анатолієвна Михайленко Віктор Міхайлович Сергієнко Тетяна Карлівна popup.nrat_date 2020-04-02 Close