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Information × Registration Number 0211U013271, 0110U005553 , R & D reports Title Complex project: Interaction between nanoscale materials with normal and tumor cells, development of methods of their delivery safety of their use. popup.stage_title Head Chekhun Vasyl Fedorovych, Registration Date 12-01-2012 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 We investigated the influence of gold nanoparticles and multiwalled carbon nanotubes (MsUNT) in a biocompatible form on morphofunctional and immunological and toxicological characteristics of tumor cells (Ehrlich ascites kartsenoma - EAK) in the in vitro and in vivo. In the study of cytomorphological characteristics of tumor cells with Ehrlich ascites carcinoma was found that the greatest pathological changes were observed in the liver and kidneys. Action (MsUNT) on the immune system of animals with EAC associated with a reduction of the relative weight and cellularity of immune competent authorities, a significant increase in spontaneous cell proliferation and mitogenindutsirovannoy that videtelstvuet on the activation of T-and B-cell immune response. In addition, the observed significant decrease in the number of lymphocytes that were apoptotic at 2 days after injection (MsUNT), which correlates with a significant reduction of lipid peroxidation. Nanocomposites consisting of gold nanoparticles and lectin tsitotoksicheskoy cause a cytotoxic effect on the internal organs of intact animals to a greater extent in the hepatocytes of the liver and kidney tubular epithelium klubochechnyh, but the degree of manifestation of degenerative changes do not lead to significant structural changes in organs and therefore can not affect their function. Product Description popup.authors Єлєйко-Хемич Любомира Олегівна Бєлова Оксана Борисівна Бондар Володимир Васильович Віннічук Юлія Дмитрівна Ганжа Олена Борисівна Главін Олексій Анатолійович Гуляй Ніна Йосипівна Дідківська Лідія Павлівна Лісовенко Галина Степанівна Лук'янова Наталія Юріївна Маковецька Людмила Ігорівна Мамчур Анатолій Анатолійович Михайленко Віктор Михайлович Налєскіна Леся Анатоліївна Прокопенко Ігор Вікторович Танасієнко Ольга Андріївна Тодор Ігор Миколайович Чехун Василь Федорович Шишко Євгенія Денисівна popup.nrat_date 2020-04-02 Close