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Registration Number

0211U013335, 0111U007399 , R & D reports

Title

Molecular design and cell investigation of novel oligoelectrolyte nanocarriers for targeted drug and gene delivery

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Head

Oleksandr Zaichenko,

Registration Date

23-12-2011

Organization

Lviv Polytechnic National University

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Water-soluble complexes have been synthesized via immobilization of drug preparations of Doxorubicine and Levomicetine on oligoelectrolytes of anionic type on the basis of vinyl acetate and maleic anhydride. Colloidal-chemical properties of this complexes have been studied and optimal ratio of components has been determined. Non-toxicity of synthesized oligoelectrolytes and increase of Doxorubicine and Levomicetine activity in complexes in comparison with clear preparations have been shown by experimental in vitro and in vivo investigations of biological activity of oligoelectrolytes and their complexes with Doxorubicine and Levomicetine. Recommendations about possible application of project results in medicine and pharmaceutical industry have been developed.

Product Description

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Іваницька Людмила Андріївна
Заіченко Олександр Сергійович
Мітіна Наталія Євгенівна
Скорохода Тарас Володимирович
Філяк Євген Зеновійович

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2020-04-02