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Registration Number

0211U013344, 0111U007041 , R & D reports

Title

Synthesis and physicochemical characteristics of directed transport nanosystems for medical and biological applications

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Head

Storozhuk Lyudmyla Petrivna, к.х.н.

Registration Date

23-12-2011

Organization

Institute of Surface Chemistry of the National Academy of Sciences of Ukraine

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Technique for synthesis magnetically operated nanocomposites based on transition metals oxides (MeFe2O4, Me = Fe2+, Ni2+, Co2+) with biologically compatible coating (SiO2)x were developed and optimized. Tetraethoxysilane (TEOS) and sodium silicate were used as precursors for formation of SiO2 onto surface of magnetic component. Content of SiO2 in nanocomposite surface layer were adjusted from 0,1 to 1,0 g for 1,0 g of magnetic component. Using a variety of physicochemical methods was revealed interconnection between structure, composition and magnetic properties of nanocomposites. It was shown that values of specific magnetization at saturation for nanocomposites magnetic component/SiO2 with content of nonmagnetic phase 0,2 g per 1 g of magnetic is close to those for initial magnetic phase. Decreasing of specific magnetization at saturation of samples and nonlinear change of coercive force with increasing of silicon dioxide content has been revealed. Adsorption interaction of immunoglobulin (Ig) and DNA with surface layers of magnetically operated nanocomposites was investigated. It has been found that adsorption of Ig and DNA amounts to ~ 0,5 mg and 0,55-0,6 mg respectively per 100 mg of adsorbent. Revealed that take place complete desorption of Ig and DNA from surface of investigated nanocomposites.

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Мудрак Іван Михайлович
Хуторний Сергій Валерійович