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Information × Registration Number 0211U013362, 0110U006127 , R & D reports Title Development of the system for growth inhibition of brain tumors on the basis of nanoconjugates of antisens-oligonucleotides and antibody, specific for oncoproteins, with natural bioplymers popup.stage_title Head Kavsan Vadym Moiseevitch, Registration Date 26-12-2011 Organization Institute of Molecular Biology and Genetics popup.description2 The aim of the project is development and creation of the system for the suppression of the growth of brain glial tumors by nanoconjugates with new effective targeted antitumor drugs. It will be created nanoconjugates of natural polymer poly-beta-malic acid (poly-malic acid, PMLA) from microorganism Physarum polycephalum, with antisense CHI3L1 mRNA oligonucleotides or CHI3L1-siRNA, and other functional modules. Nanoconjugates will be used in in vitro experiments for the antisense inhibition of protein target. Design and synthesis of antisense oligonucleotides to CHI3L1 mRNA was carried out during second stage of the project fullfilment. Different variants of PMLA conjugates with particular functional modules were obtained. Eukaryotic cell line, stably producing potential oncoprotein CHI3L1, was created. Oncogenic properties of the cells were characterized. Product Description popup.authors Єршов Антон Вікторович Балинська Олена Вікторівна Дмитренко Володимир Володимирович Дубей Лариса Василівна Костенко Олександр Миколайович popup.nrat_date 2020-04-02 Close