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Information × Registration Number 0211U013466, 0111U005413 , R & D reports Title Molecular mechanisms of antitumor activity of a new derivative maleimides. popup.stage_title Head Kharchuk Irina, Registration Date 04-01-2012 Organization Taras Shevchenko Kiev university popup.description2 Derivatives maleimidu MI-1 in their ability to inhibit the viability of malignant cells is most effective on osteosarcoma cells MG-63 cells viability of neuroblastoma line SK-N-AS MI-1 significantly inhibits only when exposed to the maximum concentration, the livelihoods of ovarian cancer cell line SK-OV-3 is inhibited to a lesser extent. For fibroblasts perodontalnoyi ties characteristic relatively high degree of survival under the influence of MI-1, alveolar osteoblasts are sensitive to the action of MI-1 for 4 hours, since the concentration of 1µM - cell survival is 65% for 24-hour exposure reduced survival to 50 % occurs when the action is the lowest concentration studied. This indicates the possibility of launching processes reperatyvnoho remodeling of alveolar bone in applying MI-1. Product Description popup.authors Рибальченко В. Харчук І. popup.nrat_date 2020-04-02 Close