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Information × Registration Number 0212U000511, 0110U000181 , R & D reports Title Analysis of neurobiological mechanisms in forming of long-term neuropsychiatric effects after the evolutionary brain's irradiation popup.stage_title Head Loganovsky Kostyantyn Mykolayovych, Bazyka Dimitry, Registration Date 16-02-2012 Organization Research Centre for Radiation Medicine popup.description2 Object of study: It is inspected 80 persons irradiated at the age of 0-1 years and 40 unexposed persons born in 1985-1986. Purpose of phase 2011: to give neuropsychiatric characteristics of persons exposed at the age of 0-1 years following the Chernobyl disaster and identify specific immunological and molecular-biological changes in brain damage in early childhood. Methods - сlinical, neuropsychological, neurophysiological, іmunological, statistical. A local database of persons exposed at the age of 0-1 years following the Chernobyl disaster was found. Increase in the frequency of nervous system and mental diseases (through somatoform, anxiety and depressive disorders) was found. Trend towards lower verbal IQ and general IQ was found with normal level of non-verbal IQ. Neurophysiological features was found - reducing the delta, theta, alpha-i power more in the fronto-temporal regions of the left hemisphere, which may indicate a decrease in activity of the hippocampus. Trend aimed at blocking the entry of lymphocytes in apoptosis was found. Changes in the immune system that can lead to autoimmune processes and disturbance antitumaral and antiviral immune responses. Obtained the first data on the biological mechanisms of radiation-induced lesions of the developing brain. The pathogenesis of neurocognitive deficits and neurophysiological disorders may consist of radiation-induced telomere shortening and apoptosis. 7 scientific publications are published, 5 reports at conferences and seminars. Product Description popup.authors Ільєнко Ірина Миколаївна Андоній Галина Вікторівна. Антипчук Катерина Юріївна Бєляєв Олег Анатолійович Бєляєва Надія Володимирівна Бабенко Тетяна Федорівна. Бомко Марія Олександрівна Гасанов Анвер Аждарович Голярник Наталія Анатоліївна Гресько Марина Володимирівна Зданевич Наталія Анатоліївна Колосинська Олена Олександрівна. Крейніс Георгій Юрійович Куц Костянтин Володимирович Логановська Тетяна Костянтинівна Лясківська Олена Володимирівна Мазніченко Оксана Леонідівна Чумак Станіслав Анатолійович Чупровська Наталія Юріївна popup.nrat_date 2020-04-02 Close