Search academic texts

Information × Registration Number 0212U000513, 0110U000230 , R & D reports Title Study of genetic mechanisms of the multifactorial pathology development in the clean-up workers of the accident on CNPP and members of their families in a long-term postaccident period popup.stage_title Head Bebeshko V.G., Minchenko J. N., Registration Date 16-02-2012 Organization Research Centre for Radiation Medicine popup.description2 Object: clean-up workers of the accident on CNPP and members of their families in a long-term postaccident period - 10 families of clean-up workers. The purpose: to study polymorphism immunogenetic, dermatoglyfic characteristics and a spectrum of molecular-cytogenetic infringements at clean-up workers of the accident on CNPP and members of their families. Methods: clinical, immunogenetic, cytogenetic moltcular-genetic, dermatoglyfic. Polymorphism of the basic genetic systems of blood (HLA - genotyping on loci A, B, C, DRB1, DQA1, DQB1 and systems ABO) in groups of priority supervision is investigated. To risk factors of occurrence oncogematological diseases are related HLA-А29 and HLA-АЗЗ, and also HLA-DRB1*12, HLA-DQA1*0103, DQA1*0501. Immunogenetic specificity DRB1*04, DQA1*0201, DQB1*0602 are related to risk factors of development cardiovascular diseases. Features of dermatoglific complex under qualitative and quantitative characteristics in groups of priority supervision among clean-up workers of the accident on CNPP and members of their families are determined. The most informative dermatoglyfic complexes structures with genes systems HLA correlating with various variants of clinical current of a sharp leukaemia at patients, development of complications leukemic process are determined. Cytogenetic and molecular-cytogenetic parameters of children of liquidators of failure on ЧАЭС 1983-1985 of a birth did not exceed control values and changed within the limits of a mistake of a method. Product Description popup.authors Білий Давід Олександрович Дмитренко Олена Олександрівна Кучер Олена Володимирівна Мішаріна Жанна Анатоліївна Федоренко Віра Григорівна Шляхтиченко Тетяна Юріївна Юрчук Єгор Анатолійович popup.nrat_date 2020-04-02 Close