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Information × Registration Number 0212U000548, 0110U004749 , R & D reports Title Charged nanoparticles as regulators of excitability of nerve cells: a new approach for epilepsy treatment popup.stage_title Head Krishtal O.A., Registration Date 17-02-2012 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 Epilepsy is a severe neurological disorder which substantially reduces the quality of life. As a result of this interdisciplinary study we synthesized a new charged nanoparticles are able to regulate the activity of sodium voltage-operated ion channels in various experimental models. This change in the activation of sodium channels increases the threshold of action potential and reduces the overall excitability of the neural network. In animal models is the reduction of pathological synchronization of neural networks leads to the suppression of seizures. Product Description popup.authors Ісаєв Д.С. Ісаєва О.В. Кришталь О.О. Максимюк О.П. Ніколаєнко Л. М. Савотченко А.В. Хмиз В.В. popup.nrat_date 2020-04-02 Close