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Registration Number

0212U000587, 0109U001640 , R & D reports

Title

Influence of immunological imbalance in the course of acute coronary syndrome in patients with persistent herpes infection

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Head

Peremot Svetlana Dmitrivna,

Registration Date

28-02-2012

Organization

The Mechnikov Research Institute of microbiology and immunology at Kharciv

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Objective - Increase the effectiveness of treatment and secondary prevention of acute coronary syndrome in patients with persistent herpes infection through the development and introduction into clinical practice of comprehensive anti-virus program immunorehabilitation. Object of research - patients with coronary heart disease with persistent herpes infection. Methods of research - immunological, virological, and laboratory klinichniko, statistical (experimental treatment studies). Results and novelty - Using methods of laboratory diagnosis in leukocytes of all patients with acute coronary syndrome and coronary heart disease identified markers representatives herpesvirusiv. Most often encountered antigen CMV, VEB, HHV6 and HSV1. Almost 90% of patients manifested two or more antigens simultaneously herpesvirusiv. In most cases determined by the Association antigens CMV-VEB and CMV-HSV: 47% and 40% respectively. In the group of patients with GCS value of mean fluorescence index ranged from 20 to 70 percent with a maximum IF in the defeat of leukocytes viruses EBV and CMV, to 80-90%, respectively. As a result of a comprehensive study of immunocompetent cells revealed that persistent herpes infection is associated with overexpression of proinflammatory cytokines, C-RB, indicating that its effects on intra vascular inflammation, which in turn increases the risk of thrombotic complications and can be regarded as a sign of unfavorable course of ACS. Stable angina is characterized by high levels of inflammatory cytokines IL-4 and IL-10 at normal values ??of IL-1, IL-6, TNF-?. Destabilization of coronary heart disease is accompanied by increased levels of proinflammatory cytokines and decreased levels of anti-inflammatory. The most significant changes in cytokine status are acute coronary syndrome, combined with persistence herpes antigens in imunotsytah. A method of predicting the risk of acute coronary syndrome in patients with coronary artery disease, infected virus family Herpesviridae. The use of specific antiviral imunohlobulinoterapiyiyi in treatment of patients with acute coronary syndrome, which unfolds against the backdrop of persistent herpes infection is pathogenetically substantiated. Under the influence of specific antiviral immunoglobulin treatment reduced levels of C-RB 2.4 times, TNF-? 2.3 times, and IF leukocytes by 24%. Dynamics of lipoprotein in the group of patients with ACS who are at high risk of coronary events after application of specific imunohlobulinoterapiyi spacecraft shows a decline by 1.5 times and a tendency to normalize the levels of LDL-cholesterol and LDL-HDL. Stabilization of CHD in the subgroup of patients who received antiviral immunoglobulins, almost a half times the corresponding figure of the group of patients with ACS who received only conventional basic therapy, accompanied by clinical deterioration in 13.3% of patients and resulted in 2 cases with fatal coronary events. Areas of Application - cardiology, clinical immunology. Results of research is recommended to implement the work cardiological departments of medical institutions of the Ministry of Health of Ukraine, specialized research institutes NAMNU and MoH.

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Ігумнова Н.І.
Волянський А.Ю.
Кашпур Н.В.
Перемот С.Д.
Перемот Я. О.
Романова О.А.
Сидоренко Т.А.
Смілянська М.В.
Целуйко В.Й.
Юхименко В.І.