Search academic texts

Information × Registration Number 0212U000589, 0109U001639 , R & D reports Title Clinical and immunological features of the course of osteoarthritis in patients with metabolic syndrome popup.stage_title Head Grishyna Olena Igorivna, Registration Date 28-02-2012 Organization The Mechnikov Research Institute of microbiology and immunology at Kharciv popup.description2 The object of study - patients with osteoarthritis (OA) and the metabolic syndrome (MS). Purpose - to study the role of the functional state of the immune system in shaping the clinical features of OA in patients with MS and development on this basis, the differentiated treatment regimens. Methods of research - clinical, instrumental, biochemical, immunological. Results and novelty - the first to demonstrate that patients with MS OA is more severe. Associated cardiovascular disease also significantly more frequent in the OA patients with MS. In patients with OA of the changes in the MS immune status is more pronounced than s patients only with OA or MC. The levels of proinflammatory cytokines - tumor necrosis factor (TNF)-alpha, interleukin (IL) 6, IL-8 is higher in patients with OA of MS than patients without MS OA and the level of anti-inflammatory cytokine transforming growth factor (TGF) beta - on the contrary has been below . Therapy chondroitin sulfate and glucosamine hydrochloride in patients with OA with MS within three months led to clinical improvement in patients. The positive dynamics of immunological indices reflected in lower levels of CD25 +, immunoglobulin classes A and M, as well as the proinflammatory cytokines TNF-alpha, IL-6, IL-8 and increased levels of anti-inflammatory cytokine - TGF beta. Product Description popup.authors Бабінець Ольга Михайлівна Волянська Наталія Петрівна Гіржанова Інна Владленівна Довга Інна Миколаївна Коляда Олег Миколайович Менкус Олена Валеріївна Мурадян Ольга Василівна Чернявський Віталій Ілліч popup.nrat_date 2020-04-02 Close