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Information × Registration Number 0212U000947, 0109U002118 , R & D reports Title Development and improvement of methods analysis of phenylpropanoid plant composition with hypolipidemic and antiaterosclerotyc activities popup.stage_title Head Tsurkan Alexander A., Yarosh Alexander K., Registration Date 14-06-2012 Organization State Establishment "Institute of Pharmacology and Toxicology National Academy of Medical Science of Ukraine" popup.description2 Aim: Search for standardization of markers of plants containing compounds fenipropanoyidnoyi nature study and hypolipidemic activity of some of them. The objects of research - medicinal herbs: Echinacea purpurea L., Melissa officinale L., Urtica dioica L., Morus nigra and alba L., Eleutherococcus senticosus, Aesculus hippocastanum L., Trifolium pratense L., Ginkgo biloba, Crataegus oxyacantha L. Methods: chromatographic (TLC, HPLC, HRH), UV spectrophotometry, chemical, biological (studies in vivo). To address one of the topical problems of modern pharmacy - standardization of multicomponent herbal remedies presents a new methodology for the analysis of plant mixtures based on use marker compounds. With the application of this methodology for the first time a set of analytical methods for qualitative and quantitative standards to potential and existing multi-herbal remedies these herbal components: Echinacea purpurea L., Melissa officinale L., Urtica dioica L., Morus nigra and alba L., Eleutherococcus senticosus, etc. The developed method tested on registered pharmaceutical market of Ukraine multicomponent herbal remedies.As a result of biological studies of single and multi-dried extract of Ginkgo biloba, red clover and horse chestnut is set as follows: plant extracts prolonged the time of thrombus formation in animals with hyperlipidemia caused by the introduction Tritons WR-1339 in doses of 500 mg / kg: chestnut and ginkgo respectively by 58 % and 79% and 124% in clover; In a simulated hyperlipidemia herbal extract chestnut oppressed increase lipid component of the study animals with a primary effect on triglyceride levels, clover extract - mainly reduced cholesterol and low-density lipoprotein, and ginkgo biloba - cholesterol, lipoproteins of high and low density. Product Description popup.authors Єфімцева Тетяна Костянтинівна Барчина Олена Ігорівна Бобков Василь Миколайович Гергель Олександр Васильович Голембіовська Олена Ігорівна Гудзенко Андрій Вікторович Джан Тетяна Вітальївна Дубравіна Алла Михайлівна Ковальчук Тетяна Василівна Козир Анатолій Віталійович Колядич Олена Павлівна Солеймані Алігударзі Марина Василівна Шаяхметова Ганна Михайлівна popup.nrat_date 2020-04-02 Close