Search academic texts

Information × Registration Number 0212U000948, 0112U000829 , R & D reports Title The mechanisms of the tolerance development to antidepressant and work the ways it overcoming popup.stage_title Head Gromov Leonid Oleksandrovich, Registration Date 14-06-2012 Organization State Establishment "Institute of Pharmacology and Toxicology National Academy of Medical Science of Ukraine" popup.description2 The every day a one-time administration of antidepressants during 7-14 days caused the tolerance development to normasidol, amitriptilynum, fluoxetinum both in the Porsolt test-model and in reserpin "depression model". The combined administration of normasidol and puracetam of the tolerance development to the normasidol antidepressant effect. It was registed cross-tolerance to fluoxetinum in the animals tolerant to amitriptilynum antidepressant effect. The latter didn't exist among the other preparations. It was found out the mechanisms of the tolerance development and the ways it. Product Description popup.authors Ворожбит Анастасія Петрівна Гончар-Чердаклі Лідія Григорівна Мовчан Олена Дмитрівна Осадчук Кристіна Олексіївна Пішель Володимир Ярославович Черноштан Константан Олександрович popup.nrat_date 2020-04-02 Close