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Information × Registration Number 0212U001346, 0110U004648 , R & D reports Title Optical sensor systems based on nanostructured molecularly imprinted polymer membranes for environmental monitoring and medical diagnostics popup.stage_title Head Sergeyeva Tetyana Anatoliivna, Доктор медичних наук Registration Date 02-02-2012 Organization Institute of Molecular Biology and Genetics popup.description2 UPolymeric membranes with nano-sized binding sites capable of selective recognition of low-molecular weight metabolites - markers of some pathologies (in particular, creatinine) were synthesized using the method of molecular imprinting. Analytical systems for creatinine detection based on the nano-structured MIP membranes provide highly-selective and sensitive creatinine detection (detection limit - 250 uМ), which is comparable to the sensitivity of traditional colorimetric and instrumental analytical methods. Stability of the developed sensor systems based on the nanostructured polymers is significantly higher as compared to the stability of the similar devices based on natural enzymes. The storage stability comprises 12-18 months under storage at room temperature. The structure of the nano-sized creatinine-binding sites in the nanostructured MIP membranes was predicted and optimized using the methods of computational modeling. A possibility of application of the developed sensor systems for creatinine detection in both model and real (dialysis liquid) samples was demonstrated. Product Description popup.authors Білоіван О.А. Калініченко Л.О. Кухта П.А. Сергеєва Т.А. Солдаткін О.П. Стадник О.Л. popup.nrat_date 2020-04-02 Close