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Information × Registration Number 0212U001540, 0109U002265 , R & D reports Title Influence of melatonine on an internal of rats popup.stage_title Head Tsebrzhinsky Oleg Igorovich, Registration Date 10-02-2012 Organization Mykolayiv State University popup.description2 The research deal with the study of the excess and deficiency of melatonin (in different doses and terms) in normal and various extreme conditions (stress, karaganic inflammation of adrenokardiomiodystrofic, intoxication peroxyboratom sodium hyperkinesias, etc.) to function, histological structure, proxidant-antioxidant system of rats (heart, muscle, liver, testicular, stomach, small intestine, lung, kidney, blood, brain, PINEAL GLAND). The object of this research work - to excess and lack of melatonin. The aim of study was investigation of proxidant-antioxidant system and the functions of various organs of rats in excess and lack of melatonin, including against various influences Experiments performed on 230 white rats, male Wistar average weight of 220-260 g in the study used biochemical, physiological, cytological and statistical methods. The study was carried out using photoelektrokolorymeric CPK-2, SF-56 spectrophotometer, ionomera, laboratory centrifuges, electronic analytical balance, the thermostat and the freezer. As a result of the studies was found that most of the continued lack of melatonin contributed to peroxidation than the lung tissue and kidneys. Excess melatonin positively acting as an antioxidant by stimulating peroxidation in organs and blood of experimental animals, unlike intact. This gives ground to suggest that melatonin to activate gene expression of antioxidant enzymes requires reactive oxygen species, which are also stimulants expression of these genes. The most significant results obtained during long periods of strong light (proxydant effect) or large doses of melatonin (antioxidant effect and block protein synthesis). Has been shown that under extreme conditions melatonin does not always act as an antioxidant in some cases it showed prooxidative properties. Therefore it is necessary to limiting the use of melatonin as a hypnotic because it operates on different organ systems are not always positive. But a small research questions remain nervous, immune and endocrine regulation of the shortage and excess melatonin genetic processes at the same time. The materials of research can be used in medicine and pharmacology. Product Description popup.authors Анасевич Ярослав Миколайович Антонова Олена Іванівна Белікова Олена Іванівна Гільмутдінова Марія Шамільєвна Дмитренко Наталія Анатоліївна Казначеєва Марія Сергіївна Козирєв Андрій Віталійович Ларичева Олена Миколаївна Пшиченко Вікторія Вікторівна Семенчук Сергій Вікторович Френкель Юрій Давидович Цвях Ольга Олександрівна Цебржинський Олег Ігорович Чеботар Лариса Дмитрівна popup.nrat_date 2020-04-02 Close