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Information × Registration Number 0212U001610, 0107U009688 , R & D reports Title The study of serial biomolecular proteins in cordination of progression of epithelial tumors of female reproductive system in patients with family cancer syndrome type I. popup.stage_title Head Buchynska Lubov, Доктор біологічних наук Registration Date 14-02-2012 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 The role of inherited factor in female reproductive system cancer development has been determined and molecular biological features of family endometrial and ovarian cancer have been characterized. Genetic dispersion component to female reproductive system cancer development in endometrial cancer patients was 53,2+ 5,6%. In 19,7% of pedigrees of endometrial cancer patients of Kyiv region association of tumors corresponding to family cancer syndrome Lynch II has been revealed. In ovarian cancer patients tumor association corresponding to Lynch II and ovarian/breast cancer syndromes was determined. Endometrial tumors in patients with Lynch II syndrome characterized by high expression of р53 "wild" type (16,7±0,3%) and р21WAF1/CIP (15,3±0,4%), positive receptor phenotype (estrogen and progesteron receptors) and low proliferative potential (19,4±0,5%). Revealed expression tumor phenotype in endometrial cancer patients with family cancer syndrome Lynch II correlated with high 5-years patients survival (92,0%). In contrast, in ovarian tumors of patients with Lynch II syndrome high proliferative potential (35,0±0,8%), which associated with high PTEN expression (53,2±1,2%) and low р53 (clone DO-7) (24,8±0,6%) and р16INK4a (25,4±0,6%) expression was revealed. In ovarian tumors of patients with ovarian/breast cancer sydrome under high proliferative activity (39,0±0,8%) high expression of р53 (clone DO-7) (48,8±0,8%), р16INK4a (45,0±0,8%) and low - PTEN (27,7±0,5%) was observed. Correlation between р16INK4a, pRb, Cyclin D1 and E2F expression in ovarian tumors and clinico-morphological factors (tumor differentiation, tumor stages) and patients survival has been revealed.. Based on complex clinical, morphological, genetic and molecular studies correlation between molecular endometrial and ovarian tumor phenotype, family history of cancer and clinical outcome has been determined. Results of this study can be used for individual prognosis of endometrial and ovarian cancers in patients with family cancer syndromes. Product Description popup.authors Білик Олена Олександрівна Брєєва Ольга Володимирівна Буднікова Дарія Володимирівна Бучинська Любов Георгіївна Глущенко Надія Миколаївна Несіна Ірина Петрівна Юрченко Наталія Петрівна popup.nrat_date 2020-04-02 Close