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Information × Registration Number 0212U002569, 0109U001629 , R & D reports Title Evaluation of the role of Toll-like receptors polymorphism in the development mechanisms of immuno-mediated diseases popup.stage_title Head Kaidashev Igor Petrovich, Registration Date 27-03-2012 Organization The Higher State Educational Establishment of Ukraine "Ukrainian Medical Stomatological Academy". popup.description2 The distribution and role of Toll-like receptors 2 and 4 polymorphisms in the immunopathogenesis in healthy individuals of Poltava population and in patients with periodontitis, rheumatoid arthritis, type 2 diabetes, asthma, atopic dermatitis, in patients with common bacterial infections, sexually transmitted infections (clamidiosis, ureaplasmosis, gardnerellosis, mycoplasmosis, trichomoniasis), as well as in patients who died of coronary heart disease have been studied for the first time. The association of Toll-like receptors 2 and 4 gene polymorphisms with the increased specific IgE production has been investigated. The influence of Toll-like receptors 2 and 4 polymorphism on the functional condition of peripheral blood mononuclear cells in individuals with "wild"-type and polymorphic variants of Toll-like receptors 2 and 4 genes after the stimulation by the respective ligands with a view to clarify the pathogenesis of immuno-mediated diseases has been studied and analyzed. The bank of genetic samples has been set up for the first time. Based on the individual observation case records of the research participants, the extensive electronic database has been developed. Product Description popup.authors Ізмайлова Ольга Віталіївна Боброва Нелля Олександрівна Весніна Людмила Едуардівна Куценко Неля Леонідівна Шликова Оксана Анатоліївна popup.nrat_date 2020-04-02 Close