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Information × Registration Number 0212U004010, 0111U005654 , R & D reports Title A role IRE-1a alarm way in the growth of glioblastoma: searches of therapeutic targets for creation the antitumor preparations. popup.stage_title Head Minchenko O.H., Registration Date 12-01-2012 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 Results and development of this investigation shown increase of the expression of transcriptional repressor TBX3 and decrease - apoptosis effector PERР и transcriptional factor TBX2 mRNA in glioma cells with suppression signaling enzyme IRE-1 function, as well as increase PERР expression and decrease - TBX2 in both types of used cells in hypoxia. Genetic construct with IRE-1 сDNA containing a mutation in ribonuclease domain for selected suppression of this enzyme ribonuclease activity in glioma cells was created; which will be used for future scientific investigation. Product Description popup.authors Божко Ірина Володимирівна Кузнєцова Анастасія Юріївна Лісняк Іван Олексійович Мінченко Дмитро Олександрович Мінченко Олександр Григорович popup.nrat_date 2020-04-02 Close
R & D report
A role IRE-1a alarm way in the growth of glioblastoma: searches of therapeutic targets for creation the antitumor preparations.
Head: Minchenko O.H.. A role IRE-1a alarm way in the growth of glioblastoma: searches of therapeutic targets for creation the antitumor preparations.. (popup.stage: ). A.V.Palladin Institute of Biochemistry of National Academy of Sciences. № 0212U004010
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Updated: 2026-03-21


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