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Information × Registration Number 0212U004011, 0111U005654 , R & D reports Title A role IRE-1a alarm way in the growth of glioblastoma: searches of therapeutic targets for creation the antitumor preparations. popup.stage_title Head Minchenko O.H., Registration Date 12-01-2012 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 Results and development of this investigation shown increase of the expression of transcriptional repressor TBX3, oncogene DEK, tumor protein TPD52, regulatory protein IGFBP1, transcriptional factor FOXF1 and decrease - apoptosis effector PERР и transcriptional factor TBX2 mRNA in glioma cells with suppression signaling enzyme IRE-1 function, as well as increase PERР, TPD52 and IGFBP1 mRNA expression and decrease - TBX2 and DEK in both types of used cells in hypoxia. Genetic construct with IRE-1 сDNA containing a mutation in ribonuclease domain for selected suppression of this enzyme ribonuclease activity in glioma cells was created; these cells was transfected and stable clones was received, which will be used for future scientific investigation. Product Description popup.authors Божко Ірина Володимирівна Кузнєцова Анастасія Юріївна Лісняк Іван Олексійович Мінченко Дмитро Олександрович Мінченко Олександр Григорович popup.nrat_date 2020-04-02 Close