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Information × Registration Number 0212U004400, 0111U001425 , R & D reports Title Mechanisms of recovery of T-cell level of the immune system in acute lymphoblastic leukemia in children. popup.stage_title Head Dubey Leonid Yaroslavovych, Registration Date 09-02-2012 Organization LVIV RESEARCH INSTITUTE OF BLOOD PATHOLOGY AND TRANSFUSIONAL MEDICINE popup.description2 In children with acute lymphoblastic leukemia (ALL), significantly affects T-cell immunity due to suppressive influence of leukemic clone and cytotoxic effect of polichemotherapy program were detected. During the treatment protocol observed a significant decrease in its performance, which after completion of cytostatic therapy and for the duration of long-term remission gradually normalized, reaching a level of age norms. Indexes of T-cell immunity, including the absolute number of T lymphocytes and their subsets at different stages of treatment and long-term remission terms are non-linear recovery. The degree of violation of this immunity depends on the age of the patient. A more prolonged and deep depression is the T-lymphocytes in young children. In older children indexes of T-cell population quickly approaching normal levels, gaining the maximum value in the long-term remission. Given immunophenotyping subvariant of ALL in children the basic indexes of T-cell have their dependency changes from it. Good regeneration of basic indexes of cellular immunity were in a "pure" B and "pure" T-ALL. Moreover, during the last immunophenotyping subvariant of disease a regenerative processes are more dynamic. It is important that the presence of myeloid markers on both B-and T-blasts in the dynamics of disease processes stimulate the recovery of immunocompetent cells in the core group of children. This is especially noticeable in the B+T +My-ALL. Product Description popup.authors Мазур Лілія Петрівна Матвієв Ірина Богданівна popup.nrat_date 2020-04-02 Close