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Information × Registration Number 0212U004744, 0111U005262 , R & D reports Title Clathrochelates of transition metals as inhibitors of some enzymes of nucleic acids biosynthesis system and prospective antitumor and antiviral pharmaceuticals. popup.stage_title Head Dubey Igor, Доктор хімічних наук Registration Date 25-01-2012 Organization Institute of molecular biology & genetics popup.description2 The effect of the series of bis-clathrochelates on the activity of RNA polymerase T7 and topoisomerase I E.coli was studied in vitro. Very high level of transcription inhibition by iron(II) clathrochelates was found in nanomolar concentrations (IC50 up to 280-310 nМ). At the same time, metal complexes did not show activity in the system of DNA relaxation by topoisomerase I. Product Description popup.authors Ільченко М.М. Дубей Л.В. Костенко О.М. Криворотенко Д.В. Негруцька В.В. Швед А.Д. popup.nrat_date 2020-04-02 Close
R & D report
Clathrochelates of transition metals as inhibitors of some enzymes of nucleic acids biosynthesis system and prospective antitumor and antiviral pharmaceuticals.
Head: Dubey Igor. Clathrochelates of transition metals as inhibitors of some enzymes of nucleic acids biosynthesis system and prospective antitumor and antiviral pharmaceuticals.. (popup.stage: ). Institute of molecular biology & genetics. № 0212U004744
1 documents found

Updated: 2026-03-23


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