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Information × Registration Number 0212U004852, 0111U000376 , R & D reports Title To explore possibility of radionuclide therapy and diagnostic in coplex treatment and monitoring of medullary cancer patients popup.stage_title Head Solodyannikova Oksana Ivanovna, Registration Date 06-02-2012 Organization Ukrainian Research Institute of Oncology and Radiology popup.description2 35 patients with medullary thyroid carcinoma were exemined. The aim of the work - to improve eficacy of treatment and clerify possibility of radionuclide methods for follow up of medullary carcinoma of thyroid, to develop algorithm of radionuclide monitorin in MTC patients. Material and methods - whole body scintigraphy with 99mTc-carbomec, dynamic scintigraphy with 99mTc-carbomec, radionuclide therapy with 131I-MIBG, statistics; double-head gamma-camera "Mediso", SPECT "E CAM 180". Treatment protocol with 131I-MIBG for medullary thyroid cancer patients (MTC) had been develope. Activity of radiopharmaceutical (RPh), quantity of therapy courses was optimized based on pharmacokinetics and biodistribution of RPh.10 patients underwent the treatment. Diagnostic protocol with 99mTc-carbomec was developed with the aim of its use in further follow-up of MTC patients, including groups of patients after surgery treatment and radioisotope courses. 15 patients underwent scintigraphy with 99mTc-carbomec. Pharmacokinetics and biodistribution of 99mTc-carbomec among these patients was analysed. Technical and physics supply of dynamic scintigraphy had been performed. Use of 131I-MIBG as a part of complex treatment of MTC was estimated. Optimal time of diagnostic procedure with 99mTc-carbomec (scintigraphy or SPECT) was explored. Product Description popup.authors Войт Наталія Юріївна Джужа Дмитро Олександрович Міхайленко Валерій Євгенович Сукач Георгій Георгійович popup.nrat_date 2020-04-02 Close