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Information × Registration Number 0212U004854, 0111U000377 , R & D reports Title Developing of the maintenance therapy in breast cancer patients who receive chemotherapy, considering clinical and laboratory of toxicity prognosis factors popup.stage_title Head Syvak Liubov, Registration Date 06-02-2012 Organization Ukrainian Research Institute of Oncology and Radiology popup.description2 Subject of the research: 40 patients with breast cancer with toxic manifestations of chemotherapy treatment with FAC scheme. Aim of the study: to improve the results of the chemotherapy treatment and quality of lafe of the patients with breast cancer by the developing of the concominant therapy after the evaiuation of clinical and laboratory factors of prognosis of treatment toxicity. Method and equipments: clinical, laboratory, instrumental, statistical; US-device "Aloca", haematological analisator BC-3000, biochemical analisator "Vitros", spectrophotometr "Thermo", centrifuge "Biofuge", thermostate "Thermit". The complex of chemotherapy toxicity of the treatment with the FAC regimen (4-6 cycles) in patients with breast cancer was evaiuated. It included clinical (symptoms, physical examination), laboratory (CBC, ERS, biochemistry, urine analisys) and instrumental (ECG, echo-CG, roentgenogramma of chest, ultrasound of abdomen or CT with contrast). Polimorphysm of GSTP1 gene was evaiuated in 28 patients before the treatment with the PCR method. The study showed that FAC regimen has moderate toxicity rate (grade II-III). Main toxicity types were hematological, gastrointestinal, cardiovascular and/or skin (alopecia) toxicity. Mainly toxicity was observed after 2nd cycle of chemotherapy and its rate increased at the end of the treatment. The most important toxicity prognostic factors of the chemotherapy with FAC regimen in patients with breast cancer were age older then 45 years old, co-morbidities, especially cardiovascular and dastrointestinal system, advanced disease stages, previous cancer treatment and heterozygote genotype of GSTP1 gene Ile/Val. Chemotherapy of the breast cancer with FAC regimen with full intensity needs the development of algorithm of concomitant treatment for the prevention and fast treatment of therapy toxicity. Field of implementation: oncology. Product Description popup.authors Алексик Олена Олексіївна Аскольський Антон Вячеславович Губарева Ганна Олександрівна Кліманов Михайло Юрійович Лялькін Сергій Анатолійович Майданевич Наталя Миколаївна Свергун Наталя Миколаївна Сивак Любов Андріївна Філоненко Катерина Сергіївна Шевчук Леся Анатоліївна popup.nrat_date 2020-04-02 Close