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Information × Registration Number 0212U004856, 0110U002202 , R & D reports Title To study efficiency of antineoplastic action of complex of magnetic micro- and nanoparticles and doxorubicin at an electromagnetic irradiation in an experiment popup.stage_title Head Schepotin I.B, Registration Date 06-02-2012 Organization Ukrainian Research Institute of Oncology and Radiology popup.description2 The object of study - magneto sensitive cocomplex from micro-and nanoparticles Fe3O4 with KCl, doxorubicin; radiopharmaceutical 99mTc-pirfoteh; cell lines of mice and Lewis lung carcinoma cell line of human non-small cell lung cancer - A-549; an experimental models of animals tumor growth: carcinosarcoma Walker-256 , Guerin's carcinoma, doxorubicin-resistant Guerin carcinoma, Lewis lung carcinoma. Equipment: mechano-magneto-reactor; apparatus for a local short-inductothermy "Magnitherm" (Radmir, Ukraine), mercury thermometer S195 (Medisana AG, Hilden, Germany); spectrophotometer NanoDrop 1000 ("Thermo Scientific", USA). The purpose - to investigate the efficacy of antitumor activity of the complex magnetic micro-and nanoparticles and doxorubicin with electromagnetic radiation in experimental models of cancer. Methods of study - physicotechnical, physicochemical, laboratory, radioisotope and statistics. Developed multifunctional complex with the paramagnetic doxorubicin and bioengineering technologies to deliver its target in malignant tumors. The method of scintigraphy directly visualized the accumulation of a multifunctional complex magnetosensitive synthesized from the radiopharmaceutical 99mTc-pirfoteh in carcinosarcoma Walker 256. In experimental models of tumor growth: Guerin's carcinoma, doxorubicin-resistant Guerin carcinoma and Lewis lung carcinoma showed that the efficacy of antitumor magneto sensitive cocomplex complex and radiofrequency hyperthermia was 26% more than the effect of officinal doxorubicin, according to the calculation of tumor volume in the last period of observation. Experimentally confirmed the role of topoisomerase II mediated amplification of antitumor effects of doxorubicin under the influence of electromagnetic radiation. Changes in the content of the complexes of heme and non-heme iron with nitric oxide activity FeS-proteins electron transport chain of mitochondria are most pronounced in the tissues of the tumor and liver of animals after administration magneto sensitive cocomplex and radiofrequency hyperthermia than by the action of oficinal doxorubicin. Conducted mathematical analysis and developed a nonlinear biophysical model of antitumor effect magneto sensitive cocomplex and radiofrequency hyperthermia for malignant tumors formalized deal of tasks targete delivery and free radical activity of the drug. Field of application - oncology. MALIGNANT TUMORS, NANOPARTICLES, MAGNETO SENSITIVE COCOMPLEX, RADIOFREQUENCY HYPERTHERMIA. Product Description popup.authors Бездєнєжних Н.О. Дзятковська І.І. Дзятковська Н.М. Крючков Є.І. Ніколов М.О. Орел В.Е. Рихальсбкий О.Ю. Романов А.В. popup.nrat_date 2020-04-02 Close