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Information × Registration Number 0212U005134, 0108U010563 , R & D reports Title Implication of oxidative stress in xenobiotics induced ageing and beneficial effects of antioxidants popup.stage_title Head Bozhkov Anatoliy, Registration Date 26-03-2012 Organization Kharkov National University named after V.N. Karazin popup.description2 Object study - postmitochondrial fraction, 2-14-months age of rats, culture yeast Saccharomyces cerevisiae and Drosophila melanogaster. Methods - differential centrifugation, spectrophotometry, polarography biochemical analysis of enzyme activity and metabolites content. The culture of yeast Saccharomyces cerevisiae shows that the concentration the most effect on culture viability, influence lead cells. These phenomena submissions may be connect with an increase of level free radical processes. The most dangerous for Drosophila melanogaster is a xenobiotic cadmium. The negative impact of the metal may be aggravated by the combined action of lead and ethanol. Negative impact on the viability of the insects when introduced into the food mixture is investigated xenobiotics may be associated with activation of oxidative damage to cells of biopolymers with appropriate consequences. In Wistar rats found a significant effect on the cadmium content of hemoproteins and the overall activity of the monooxygenase system in animals of different ages. Was significantly less impact on the state of this system in ethanol, especially in young animals. The data obtained indicate the possibility of interference of ethanol in the mechanisms of toxic action of cadmium Product Description popup.authors Асадова М. Білосьлцька Л. Давидов В. Дзюба В. Козлов О. Леонова І. Мензянова Н. Нікітченко Ю. Падалко В. Сисенко О. Щелбанов М. popup.nrat_date 2020-04-02 Close