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Information × Registration Number 0212U005156, 0107U000301 , R & D reports Title Cloning and heterologous expression of microorganisms' and plants' genes encoding enzymes degrading arginine and its biosynthetic precursors; elucidation of mechanisms of their action and use for inhibiting growth of malignant cells in vitro and in vivo popup.stage_title Head Sibirny Andriy Andriyovych, Registration Date 27-03-2012 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 Arginine deiminase gene of Mycoplasma hominis and ornithine transcarbamylase gene of Pseudomonas aeruginosa were cloned. The expression of these genes was optimized for Escherichia coli. The effects of purified preparations of these enzymes in the form of monotherapy and in combination with chemotherapeutical agents were investigated on the models of human and animal malignant cells in vitro. The influence of low-carbohydrate diet in combination with compounds that inhibit glycolysis on NK/Ly lymphoma cell growth in tumor-bearing mice BALB/C was studied. Product Description popup.authors Борецький Юрій Романович Гончар Михайло Васильович Луцик Максим Дмитрович Стасик Олег Володимирович Стойка Ростислав Степанович popup.nrat_date 2020-04-02 Close
R & D report
Cloning and heterologous expression of microorganisms' and plants' genes encoding enzymes degrading arginine and its biosynthetic precursors; elucidation of mechanisms of their action and use for inhibiting growth of malignant cells in vitro and in vivo
Head: Sibirny Andriy Andriyovych. Cloning and heterologous expression of microorganisms' and plants' genes encoding enzymes degrading arginine and its biosynthetic precursors; elucidation of mechanisms of their action and use for inhibiting growth of malignant cells in vitro and in vivo. (popup.stage: ). Institute of cell biology, National Academy of Sciences of Ukraine. № 0212U005156
1 documents found

Updated: 2026-03-21


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