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Information × Registration Number 0212U005470, 0110U003453 , R & D reports Title Examination of the temporal turn off mechanisms of immune control genes of female's reproductive sphere tumours by interfering ribonucleic acids. popup.stage_title Head Zaporozhan Valery Nikolaevich, Registration Date 26-11-2012 Organization Odesa National Medical University popup.description2 The study of quantitative indicators density and functional activity of dendritic cells in euthyroidism and in violation of thyroid status in rats conducted. The dependence between changes in thyroid function and functional population of dendritic cells in the experiment is fixed. The influence of extremely high frequency (EHF) radiation in experimental adenocarcinoma found that the effect of EHF (15.0 min) causes a significant increase of the reliable experimental tumors compared with animals that were not exposed to EHF. Found that through the use specific antigen / turbofrofect invitro transfection reagent R-0537/siRNA transfector with dendritic cell dimensions of experimental tumors decreased in average of 27 percent in the group of rats with experimental hypothyroidism and 15 percent in the group of rats with experimental hyperthyroidism. Decreased degree of malignancy of tumors, more pronounced changes registered in the group of hypothyroidism were also revealed. A study of dendritic cell markers CD1a + and CD83 in cervical vyshkrebku patients with cervical intraepithelial neoplasia. Found a significant decrease in the population of immature CD1a + and CD83+ mature dendritic cells. The study of population of dendritic cells in the endometrium of women with hyperplasia was done. The study found a high level of proliferation of cells and investigated their association with clusters of CD56 + natural killer cells and cytotoxic lymphocytes CD83+. Determined that the recurrence of cervical pathology after treatment was observed mainly in women with depression maximum population of CD1a+ and CD83+ cells in the cervical epithelium, with a relative risk of relapse was 1.3 (0.9; 1.7) to reduce CD1a + less than 2, 0 in the field of view and 1.5 (1.1, 1, 9) for CD83 + cells less than 0.015 in sight. Thus, the depletion of the population of mature dendritic cells in patients with cervical background is more important prognostic factor. These data indicate a gradual Reduced immunological properties of dendritic cells in patients with various degrees of progression of cancer process. Showed also that different clusters of differentiation have different physical properties. This gives grounds to justify the treatment of cancer by modulation of activity of dendritic cells, including using natural methods. Product Description popup.authors Андронов Дмитро Юрійович Грушко В’ячеслав Володимирович Запорожан Валерій Миколайович Марічереда Валерія Геннадіївна Мещерякова Наталя Володимирівна Пономаренко Андрій Іванович Сторчило Ольга В’ячеславівна popup.nrat_date 2020-04-02 Close