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Information × Registration Number 0212U005479, 0110U006658 , R & D reports Title Search and complex investigation of the pharmacological profile of new biologically active compounds of metabolite origin and xenobiotics popup.stage_title Head Kresyun Valentin Iosephovich, Registration Date 26-11-2012 Organization Odesa National Medical University popup.description2 The object of research - finding of novel highly effective and safe neurotropic pharmacological agents. The subject of research - study of neuropharmacological activity of novel derivatives of 1,4-benzodiazepines and PABP. Methods of research - pharmacological, pathophysiological, statistical. In presented work it is found low toxicity and presence of sedative activity in 3-amino- and 3-arilidensubstituted derivatives of 1,4 - benzodiazepine - 2-ones. It is established an anticonvulsant activity in peptidamidobenzophenone derivative (PABPhD) upon the development of drug-resistant form of kindling syndrome. The effective dosage (ED50) of PABPhD in conditions of acute seizers are calculated. The maintenance of anticonvulsant efficiency of PABPhD upon postponed kindled seizures have been established. Behavioral disturbance in kindled rats have been abolished succesfully by PABPhD, and this effect was observed in grater range of dosages (0,15-1,5 mg/kg, i.p.) than diazepam. It was shown that PABPhD caused the increase of the high-frequency beta and gama bandwidth bioelectric oscillations power in frontal brain cortex. Product Description popup.authors Андронов Дмитро Юрійович Антоненко Катерина Олексіївна Антоненко Петро Борисович Волощук Людмила Гіляріївна Годлевський Леонід Семенович Годован Владлена Володимирівна Казакова Анастасія Анатоліївна Кресюн Валентин Йосипович Мніх Валентина Петрівна Остапчук Катерина Володимирівна Погоріла Ірина Вікторівна Скуртол Юлія Володимирівна Тимчишин Олег Львович Шемонаєва Катерина Федорівна popup.nrat_date 2020-04-02 Close