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Information × Registration Number 0212U005490, 0111U003343 , R & D reports Title Study of infectious disease trigger on immunological mechanisms of autoimmune reactions formation popup.stage_title Head Protchenko Pavel Zakharovich, Registration Date 26-11-2012 Organization Odessa State Medical Universitu popup.description2 Patients with evidence of systemic lupus erythematosus (SLE), scleroderma (SCl), rheumatoid arthritis (RA) were tested for antibodies to hepatitis B and C (HBV and HCV), parvovirus B 19, Brucella, Toxoplasma, and E. histolytica. In the group of patients with autoimmune diseases seropositivity to all examined viruses and Toxoplasma was significantly higher than in controls. Percentage of seropositivity to HBV was 16,7 ± 7,35% in the group of patients with RA and 19,8 ± 3,69% in patients with SLE, to HCV - 11,9 ± 3,95% in the group of patients with RA and 10,2 ± 2,77% in patients with SLE, to parvovirus B 19 - 77,8 ± 4,24% in the group of patients with RA and 82,1 ± 3,45% in patients with SLE, to Toxoplasma - 61,1 ± 8.12% in the group of patients with RA and 79,2 ± 6,92% in patients with SLE. Antibodies to E. histolytica detected in 7,7 ± 5,23% of patients with SLE. Antibodies to Brucella were found in only 2,9 ± 2,87% of RA patients, which excludes this pathogen as trigger in development of RA. Product Description popup.authors Боровик Альона Петрівна Кольцова Ірина Генадіївна Протченко Павло Захарович popup.nrat_date 2020-04-02 Close